Pbk positively regulates myoblast differentiation and muscle regeneration via enhancing AMPK/ULK1 mediated myogenic autophagy
Collectively, our findings suggest that Pbk plays a positive regulatory role in myoblast differentiation and muscle regeneration by modulating AMPK/ULK1-mediated autophagy signaling. This pathway may represent a novel target for the manipulation of myoblast functions and the development of myoblast-based therapies for skeletal muscle injuries.
Authors
- Dandan Zhao (ORCID: https://orcid.org/0000-0001-5194-750X)
- D. Wang (ORCID: https://orcid.org/0009-0008-5551-7919)
- Chuanzhu Yan (ORCID: https://orcid.org/0000-0002-2191-5184)
- Fuchen Liu (ORCID: https://orcid.org/0000-0002-0041-7055)
- Tingjun Dai (ORCID: https://orcid.org/0000-0003-4928-0421)
- Didi Shan
Institutions
- Qilu Hospital of Shandong University (CN)
- Qingdao Eighth People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12967-025-07173-z
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province