Activating NEDD4L suppresses EGFR-driven lung adenocarcinoma growth via facilitating EGFR proteasomal degradation
This study demonstrates that FOXM1/NEDD4L axis impairs EGFR proteasomal degradation, thus contributing to EGFR-driven LUAD growth and osimertinib resistance. Combination therapy incorporating NEDD4L activation may represent a new valued therapeutic strategy for EGFR-driven LUAD and osimertinib resistance.
Authors
- Jiani Zheng (ORCID: https://orcid.org/0000-0002-9595-7459)
- Wei Jiang (ORCID: https://orcid.org/0000-0001-6534-8612)
- Lanlan Pang (ORCID: https://orcid.org/0000-0002-4932-8117)
- Wen‐Feng Fang (ORCID: https://orcid.org/0000-0003-0350-9059)
- Maojian Chen (ORCID: https://orcid.org/0000-0002-0584-5382)
- Yunpeng Yang (ORCID: https://orcid.org/0000-0001-6987-2219)
- Jing Li (ORCID: https://orcid.org/0000-0001-7792-4322)
- Li Zhang (ORCID: https://orcid.org/0000-0001-6319-1092)
- Jianhua Zhan
- Yihua Huang (ORCID: https://orcid.org/0000-0001-6736-7913)
- Yaxiong Zhang (ORCID: https://orcid.org/0000-0002-3632-0300)
- Shaoping Zhang (ORCID: https://orcid.org/0000-0003-3364-7110)
- Jiaqing Liu (ORCID: https://orcid.org/0000-0001-8600-8932)
- Shen Zhao
- Junyi He
Institutions
- Sun Yat-sen University (CN)
- Guangxi Medical University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Sun Yat-sen University Cancer Center (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13046-025-03528-y
- Citations
- 2
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.61