CRISPR/Cas9 library screening reveals that STK19 has synergistic antitumor effects when combined with cisplatin on tongue squamous cell carcinoma
STK19 was identified as a promising target that could enhance the killing effects of cisplatin on tongue squamous carcinoma cells, offering a novel therapeutic option for individuals who are insensitive to conventional treatment methods.
Authors
- Yinghong Zhao
- Zhaoming Zhong (ORCID: https://orcid.org/0000-0003-1480-028X)
- Rujia Qin
- Lei Qian (ORCID: https://orcid.org/0000-0003-3555-4313)
- Zhi Tao
- Chongxin Li
- Xue Min Wang (ORCID: https://orcid.org/0000-0002-2038-8829)
- Feineng Liu
- Jialing Lv
- Chuanzheng Sun (ORCID: https://orcid.org/0000-0001-8284-8264)
- Zengbo Lv
- Haixia Zhang (ORCID: https://orcid.org/0000-0001-5489-5987)
- Chunyan Li (ORCID: https://orcid.org/0000-0002-9720-2631)
- Wen Peng
- Shixuan Yang
- Yong Zhang (ORCID: https://orcid.org/0000-0002-7400-5803)
Institutions
- Kunming Medical University (CN)
- Tianjin First Center Hospital (CN)
- Qujing Normal University (CN)
- People's Hospital of Kaizhou District (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12967-025-07156-0
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China