Healthy lifestyle partly mediates the association between self-rated health and risk of overall and cause-specific mortality
Poor self-rated health was significantly associated with higher risk of overall and cause-specific mortality, and these associations were partially mediated by lifestyle. A positive additive interaction between self-rated health and lifestyle was noted for overall mortality and for mortality from CVD, heart disease, cancer, and respiratory disease. These findings underscore the clinical importance of self-rated health and suggest that lifestyle modification may improve health and longevity, particularly among individuals with low or moderate self-rated health.
Authors
- Jiaqi Huang (ORCID: https://orcid.org/0000-0002-7808-9477)
- Yi Yang (ORCID: https://orcid.org/0000-0002-5808-0109)
- Linda M. Liao (ORCID: https://orcid.org/0000-0002-1923-5294)
- Stephanie J. Weinstein (ORCID: https://orcid.org/0000-0002-3834-1535)
- Demetrius Albanes
- Ben Lü (ORCID: https://orcid.org/0000-0002-8597-0406)
- Fang Fang (ORCID: https://orcid.org/0000-0002-3310-6456)
- Bin Zhao (ORCID: https://orcid.org/0000-0002-5990-1773)
- Ya Miao (ORCID: https://orcid.org/0000-0003-1208-251X)
- Kai Yu
Institutions
- Huaqiao University (CN)
- Central South University (CN)
- Karolinska Institutet (SE)
- National Cancer Institute (US)
- Second Xiangya Hospital of Central South University (CN)
- Third Xiangya Hospital (CN)
- Department of Health and Human Services (US)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12916-025-04399-y
- Citations
- 1
- Primary Topic
- Health disparities and outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.17
Funders
- U.S. Department of Health and Human Services
- U.S. Department of State
- Pennsylvania Department of Health
- California Department of Public Health
- Florida Department of Health
- Emory University
- Arizona Department of Health Services
- Rutgers Cancer Institute of New Jersey
- Louisiana State University
- Texas Department of State Health Services
- National Natural Science Foundation of China
- Central South University
- National Science and Technology Major Project
- National Institutes of Health
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
- National Key Research and Development Program of China
- National Cancer Institute