Impact of digoxin versus beta-blocker in patients with coexistent atrial fibrillation and heart failure: a target trial emulation
In patients with coexisting AF and HF, digoxin was associated with significantly higher risks of all-cause mortality, cardiovascular mortality, and heart failure hospitalization compared to beta-blocker.
Authors
- Yap‐Hang Chan (ORCID: https://orcid.org/0000-0001-5384-8468)
- Lin Liu (ORCID: https://orcid.org/0000-0002-9581-1337)
- Haochen Xuan (ORCID: https://orcid.org/0000-0002-2017-9285)
- Aimin Xu (ORCID: https://orcid.org/0000-0002-0668-033X)
- Anping Cai (ORCID: https://orcid.org/0000-0003-3953-5881)
- Gregory Y.H. Lip (ORCID: https://orcid.org/0000-0002-7566-1626)
- Jingnan Zhang (ORCID: https://orcid.org/0000-0002-4865-5212)
- Kai-Hang Yiu (ORCID: https://orcid.org/0000-0003-2145-3108)
- Jiayi Huang (ORCID: https://orcid.org/0009-0009-3927-8329)
- Wenli Gu (ORCID: https://orcid.org/0000-0002-9964-8805)
- Ran Guo (ORCID: https://orcid.org/0009-0005-0226-2789)
- Bernard M. Y. Cheung
Institutions
- Medical University of Białystok (PL)
- University of Liverpool (GB)
- Chinese University of Hong Kong (HK)
- Queen Mary Hospital (CN)
- Liverpool Heart and Chest Hospital (GB)
- University of Hong Kong - Shenzhen Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Liverpool John Moores University (GB)
- University of Hong Kong (HK)
- Aalborg University (DK)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12916-025-04408-0
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Sanming Project of Medicine in Shenzhen