BMI partially mediates the association between the non–HDL-C/HDL-C ratio and depression in obese adults
Among obese adults, higher NHHR levels are significantly associated with an increased risk of depression, with BMI partially mediating this relationship and diabetes status and smoking history serving as moderators. These findings suggest that NHHR may provide valuable insight for early intervention in mental health disorders among obese populations.
Authors
- Yilei Liu (ORCID: https://orcid.org/0009-0002-9826-8007)
- Kunyu Qiu (ORCID: https://orcid.org/0000-0001-8317-3430)
- Chengwei Hu (ORCID: https://orcid.org/0000-0003-2846-5339)
- Yanyan Huang (ORCID: https://orcid.org/0000-0002-2930-6471)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-4118-4454)
- Jie Gu (ORCID: https://orcid.org/0000-0002-7064-6769)
Institutions
- Fudan University (CN)
- Shanghai FRP Research Institute (China) (CN)
- Shanghai Changzheng Hospital (CN)
- Community Health Center (US)
- Huashan Hospital (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13098-025-01971-7
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00