Effects of antifibrotic agent Nintedanib on experimentally generated priapism model in rats
Although Nintedanib is antifibrotic in pulmonary contexts, it appears to promote penile fibrosis post-IP, likely via excessive VEGFR-2 inhibition, impairing vascular recovery and erectile function. Further studies are needed.
Authors
- İnci TURAN (ORCID: https://orcid.org/0000-0003-2211-3914)
- Salih Erdem (ORCID: https://orcid.org/0000-0003-3277-0539)
- Gökhan Çeker (ORCID: https://orcid.org/0000-0002-7891-9450)
- Reha Girgin (ORCID: https://orcid.org/0000-0003-1132-8629)
- Esin Kaymaz (ORCID: https://orcid.org/0000-0003-4127-6559)
- Önder Çınar (ORCID: https://orcid.org/0000-0002-0107-5843)
Institutions
- Zonguldak Bülent Ecevit University (TR)
- Istanbul Metropolitan Municipality (TR)
- Güven Hospital (TR)
- Samsun University (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- World Journal of Urology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1007/s00345-025-05993-8
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00