Metal ion transporter SLC39A14-mediated ferroptosis and glycosylation modulate the tumor immune microenvironment: pan-cancer multi-omics exploration of therapeutic potential
In this study, we identified SLC39A14 as a dual regulator at the interface of ferroptosis and glycosylation, with significant impacts on tumor microenvironmental remodeling and therapeutic resistance. By leveraging multi-omics and single-cell transcriptomic data, we establish SLC39A14 as a promising prognostic biomarker and therapeutic target, particularly in brain and kidney cancers where ferroptosis modulation could offer novel clinical strategies.
Authors
- Kai‐Fu Chang (ORCID: https://orcid.org/0000-0003-1640-1960)
- Chien‐Han Yuan
- Shun‐Fa Yang (ORCID: https://orcid.org/0000-0002-0365-7927)
- Chi-Jen Wu (ORCID: https://orcid.org/0000-0003-2160-8472)
- Do Thi Minh Xuan
- Ching‐Chung Ko (ORCID: https://orcid.org/0000-0002-8950-7128)
- Yung‐Kuo Lee (ORCID: https://orcid.org/0000-0003-1638-8049)
- Chih-Hsuan Chang
- Chih‐Yang Wang (ORCID: https://orcid.org/0000-0002-4137-5074)
- Damtew Solomon (ORCID: https://orcid.org/0000-0003-4831-4992)
- Hung‐Yun Lin (ORCID: https://orcid.org/0000-0003-2824-6419)
- Chung-Bao Hsieh
- Sachin Kumar
- Fitria Sari Wulandari
- Yi-Chun Chiang
- Hui-Ru Lin
- Juan Lorell Ngadio
Institutions
- Tri-Service General Hospital (TW)
- National Sun Yat-sen University (TW)
- Kaohsiung Medical University (TW)
- Taipei Medical University Hospital (TW)
- Albany College of Pharmacy and Health Sciences (US)
- Chung Shan Medical University Hospital (TW)
- Kaohsiung Armed Forces General Hospital (TW)
- Van Lang University (VN)
- Shoolini University (IN)
- Chi Mei Medical Center (TW)
- Indonesia International Institute for Life Sciences (ID)
- Wan Fang Hospital (TW)
- Taipei Medical University (TW)
- Chia Nan University of Pharmacy and Science (TW)
- National Defense Medical Center (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12935-025-04003-6
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Office of Research and Development
- Ministry of Education, India
- Taipei Medical University
- Kaohsiung Armed Forces General Hospital
- National Science and Technology Council
- Office of Research and Development, Taipei Medical University