α-Methyltryptophan mitigates cognitive impairment in db/db mice: involvement of gut-brain metabolic remodeling
These findings indicate that α-MT alleviates diabetes-associated cognitive impairment by promoting gut-brain metabolic remodeling. Targeting intestinal amino acid transport may represent a promising nutritional and therapeutic strategy for neuroprotection in diabetic encephalopathy (DE).
Authors
- Qing Yao (ORCID: https://orcid.org/0000-0003-0115-9075)
- Dan Shen (ORCID: https://orcid.org/0000-0001-8655-0166)
- Yunqiang Zhu (ORCID: https://orcid.org/0000-0002-3356-3067)
- Aimin Cai
- Ruijie Chen (ORCID: https://orcid.org/0000-0001-5453-5949)
- Xinyu Di (ORCID: https://orcid.org/0000-0002-2785-9320)
- Longfa Kou (ORCID: https://orcid.org/0000-0001-8502-4279)
- Qiushuang Xiong
- Yun Yan (ORCID: https://orcid.org/0000-0003-2605-8860)
- Zhiwei Chen (ORCID: https://orcid.org/0009-0002-9068-4401)
- Guangyong Lin
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Nutrition & Metabolism
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12986-025-01024-w
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00