Radiation- and age-related vascular dysfunction as an early indicator of cardiovascular risk: a long-term study in the ApoE−/− mouse model of atherosclerosis
Both mouse strains exhibited marked age-related vascular changes, with ApoE<sup>-/-</sup> mice showing greater radiation sensitivity. The combined effects of aging and radiation were most prominent in reduced arterial diameters at baseline and after vasoconstriction, along with slower vasodilation reflecting elevated vascular resistance linked to hypertension. Early blood pressure management is therefore essential to reduce the risk of radiation-induced CVD.
Authors
- Bettina Habelt (ORCID: https://orcid.org/0000-0001-8964-9698)
- Maximiliano Cuevas
- Wolfgang Dörr
Institutions
- University Hospital Carl Gustav Carus (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s40959-025-00395-6
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Technische Universität Dresden