The transcription factor Blimp-1 is suppressed by SLAMF1 and drives Treg cell-mediated immune evasion in non-small cell lung cancer
Here, we identify a key role of the transcription factor Blimp1 for immune evasion in NSCLC. Thus, targeting Blimp1 emerges as a novel concept to improve current lung cancer immunotherapies and to suppress immune evasion in lung cancer.
Authors
- Denis I. Trufa
- Horia Sı̂rbu
- Sonja Trump
- Andreas B. Wild (ORCID: https://orcid.org/0009-0005-6008-2874)
- Laura Neurath
- Susanne Mittler
- Patrick Tausche
- Susetta Finotto (ORCID: https://orcid.org/0000-0001-7623-7977)
- Katja Hohenberger
- Elvedina Nendel
- Nicole Neurath
- Arndt Hartmann
- Sviatoslav Tsiumpala
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- Comprehensive Cancer Center Erlangen (DE)
Publication Details
- Journal
- BJC Reports
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1038/s44276-025-00184-9
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00