Anticholinergic burden and incident dementia: a Swedish nationwide case-control study
Use of strong anticholinergics, but not weak ones, was associated with a higher risk of dementia, with the strength of association depending on cumulative dose, drug class, and dementia subtype. Caution should be exercised when prescribing drugs with strong anticholinergic properties to middle-aged and older individuals.
Authors
- Maria Eriksdotter (ORCID: https://orcid.org/0000-0003-2498-4000)
- Sara García‐Ptacek (ORCID: https://orcid.org/0000-0002-1537-6129)
- Hong Xu (ORCID: https://orcid.org/0000-0002-7266-3431)
- Sophie Liabeuf (ORCID: https://orcid.org/0000-0001-5384-9006)
- Edwin C.K. Tan (ORCID: https://orcid.org/0000-0003-2922-8837)
- Kristina Johnell (ORCID: https://orcid.org/0000-0003-0093-7699)
- Nanbo Zhu (ORCID: https://orcid.org/0000-0003-3501-1351)
Institutions
- The University of Sydney (AU)
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires (FR)
- Université de Picardie Jules Verne (FR)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13195-025-01883-8
- Citations
- 3
- Primary Topic
- Pharmaceutical Practices and Patient Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 3.67
Funders
- Karolinska Institutet
- Vetenskapsrådet
- Dementia Australia
- Center for Innovative Medicine