The Effectiveness of Phosphate-Based Bioactive Glass on Candida albicans Adherence in Dental Soft Lining Material (In Vitro Study)

Background: Denture stomatitis (DS) represents an oral fungal infection induced by Candida albicans, impacting approximately 70% of the individuals who use removable acrylic dentures. Researchers suggest that the high level of the Candida species, particularly Candida albicans (C. albicans), is the predominant etiological factor of DS. Consequently, the development of a soft liner with antifungal activity might significantly enhance its therapeutic applicability. This in vitro study evaluates the impact of phosphate bioactive glass reinforced heat-cured acrylic-based soft liner on the candidal activity in this material. Method: Specimens (10 mm × 2 mm disc-like) were required for the selected test; PBG-Sr nano-powder was synthesized and added to the soft liner at percentages of 1 wt.%, 3 wt.%, 5 wt.%, and 7 wt.%. The candidal adherence test was investigated, and characterization was performed by X-ray diffraction analysis, field emission scanning electron microscopy, energy dispersive X-ray spectroscopy mapping, and particle size analysis. The resulting data were analyzed with one-way ANOVA followed by Dunnett’s test. Results: Candidal adherence in the 1 wt.%, 3 wt.%, 5 wt.%, and 7 wt.% PBG-Sr subgroups had decreased values in comparison to the control (0 wt.%), with the 7 wt.% subgroup demonstrating the lowest count of C. albicans (0.027), close to the nystatin group. Conclusions: PBG-Sr can diminish C. albicans adhesion in soft lining materials, and a soft liner containing PBG-Sr (7 wt.%) showed the most effective activity against C. albicans in the soft liner. Soft liners infused with bioactive glass may have the potential to assist those struggling with denture stomatitis, providing patients with enhanced therapeutic qualities.