Chemotherapy-Treated Breast Cancer Cells Activate the WNT Signaling Pathway to Enter a Diapause-Like Early Persister State
WNT signaling is a crucial driver and biomarker of a reversible, dormant, diapause-like persister state in breast cancer cells, offering insights that could transform therapeutic strategies to disrupt tumor persistence.
Authors
- Paraskevi Athanasouli (ORCID: https://orcid.org/0000-0001-9504-7562)
- Frederic Lluı́s (ORCID: https://orcid.org/0000-0002-7296-7611)
- Maria Francesca Baietti (ORCID: https://orcid.org/0000-0002-1495-226X)
- Anirudh Pabba (ORCID: https://orcid.org/0000-0003-2002-6956)
- Anchel De Jaime-Soguero (ORCID: https://orcid.org/0000-0002-9358-3676)
- Stephen‐John Sammut (ORCID: https://orcid.org/0000-0003-4472-904X)
- Alessandra Qualizza (ORCID: https://orcid.org/0009-0002-2002-503X)
- François Richard (ORCID: https://orcid.org/0000-0003-4353-3619)
- Larissa Mourão (ORCID: https://orcid.org/0000-0001-8046-5366)
- Stefaan J. Soenen (ORCID: https://orcid.org/0000-0003-2390-3133)
- Wout De Wispelaere (ORCID: https://orcid.org/0000-0002-7513-9002)
- Daniela Annibali (ORCID: https://orcid.org/0000-0001-8413-7669)
- Christine Desmedt (ORCID: https://orcid.org/0000-0002-5223-5579)
- Colinda L. G. J. Scheele (ORCID: https://orcid.org/0000-0001-8999-5451)
- Youssef El Laithy (ORCID: https://orcid.org/0000-0002-8576-4231)
- Jos Jonkers (ORCID: https://orcid.org/0000-0002-9264-9792)
- Carla Ríos‐Luci (ORCID: https://orcid.org/0000-0001-8636-1509)
- Willy Antoni Abreu de Oliveira (ORCID: https://orcid.org/0000-0003-1783-4522)
- Stijn Moens (ORCID: https://orcid.org/0000-0003-3308-133X)
- Alejandra Bruna (ORCID: https://orcid.org/0000-0003-1214-9665)
- Stefan J. Hutten (ORCID: https://orcid.org/0000-0001-5395-8392)
- Gwenny Cosemans (ORCID: https://orcid.org/0000-0002-4781-1586)
- Siân Hamer (ORCID: https://orcid.org/0000-0002-0235-6786)
- Paula García-Díaz (ORCID: https://orcid.org/0009-0001-5352-8330)
Institutions
- Royal Marsden NHS Foundation Trust (GB)
- Institute of Cancer Research (GB)
- Breast Cancer Research Foundation (US)
- Rega Institute for Medical Research (BE)
- Breast Cancer Now (GB)
- Institut Jules Bordet (BE)
- The Netherlands Cancer Institute (NL)
- VIB-KU Leuven Center for Cancer Biology (BE)
- Oncode Institute (NL)
- Royal Marsden Hospital (GB)
- Stem Cell Institute (PA)
- Stichting Roomsch Catholyk Oude Armen kantoor (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4165
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00