Hydrogen sulfide induces regulatory B cells via glycolysis and mitochondrial ROS, attenuating LPS-induced lung injury
This study reveals that H<sub>2</sub>S shifts B cells to have regulatory phenotypes via shifting metabolic pathway and enhancing mitochondrial expenditure. H<sub>2</sub>S can serve as one of the inducers and environmental signals for B<sub>regs</sub> to resolve inflammation via signaling and metabolic pathways in B cells.
Authors
- Yoe‐Sik Bae (ORCID: https://orcid.org/0000-0002-6198-4512)
- Brian A. Zabel (ORCID: https://orcid.org/0000-0001-7293-6180)
- Ji Ye Park
- Byung‐Hyun Park (ORCID: https://orcid.org/0000-0003-3768-4285)
- Yu Sun Jeong (ORCID: https://orcid.org/0009-0009-1438-2840)
- Ji Cheol Kim
- Mingyu Lee (ORCID: https://orcid.org/0009-0008-0773-680X)
Institutions
- Palo Alto Veterans Institute for Research (US)
- GI Innovation (South Korea) (KR)
- Dong-A Pharmaceutical (South Korea) (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12964-025-02456-w
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Ministry of Science, ICT and Future Planning
- National Research Foundation of Korea