Single-cell transcriptomics identifies PDIA4 as a marker of progression and therapeutic vulnerability in multiple myeloma
PDIA4 is a key regulator of the unfolded protein response and MM cell survival. Targeting PDIA4 may enhance the efficacy of proteasome inhibitors and offers a potential strategy to overcome therapeutic resistance in multiple myeloma.
Authors
- Zhenyu Li (ORCID: https://orcid.org/0000-0003-4610-9135)
- Aoyang Yü (ORCID: https://orcid.org/0009-0006-0214-4771)
- Wenjie Yu
- Jiayu Zhan (ORCID: https://orcid.org/0000-0001-7271-5070)
- Can Huang
- Yanhua Liu (ORCID: https://orcid.org/0000-0002-6076-9968)
- Yu Rao (ORCID: https://orcid.org/0000-0001-6986-2643)
- Xuan Zhang (ORCID: https://orcid.org/0000-0001-8775-1699)
- Sheng-Feng Lu (ORCID: https://orcid.org/0000-0001-5600-0999)
- Xu Cao
- Chong Chen (ORCID: https://orcid.org/0009-0007-5588-7824)
- Yanxia Wang (ORCID: https://orcid.org/0009-0007-0194-5478)
Institutions
- Xuzhou Medical College (CN)
- Xuzhou Central Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12967-025-07098-7
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80