FGF10 ameliorates epileptic seizures and related cognitive dysfunction via the FGFR2/CALB1 signaling pathway
Our findings demonstrate that FGF10 alleviates seizures and cognitive dysfunction in epilepsy, likely through FGFR2-dependent mechanisms involving CALB1 modulation. These results highlight FGF10 as a potential therapeutic target for epilepsy, offering a novel strategy for improving treatment outcomes in patients with TLE.
Authors
- Huiqin Xu (ORCID: https://orcid.org/0000-0002-8856-3048)
- Xing Jin (ORCID: https://orcid.org/0000-0002-5237-0981)
- Limei Zhao (ORCID: https://orcid.org/0009-0003-5618-227X)
- Xu Zhang (ORCID: https://orcid.org/0000-0002-6908-6768)
- Liang Cheng (ORCID: https://orcid.org/0000-0003-2187-4025)
- Yaoyao Lin
- Shihao Chen (ORCID: https://orcid.org/0000-0001-5913-3236)
- Yuqing Xiao (ORCID: https://orcid.org/0009-0001-0164-8234)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12967-025-07185-9
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wenzhou Medical University