Reproductive history and cardiometabolic disease: the role of endogenous estrogen exposure across the lifespan in postmenopausal women
Longer exposure to endogenous estrogen was associated with decreased risk of cardiometabolic disease, while a higher burden of gestational events was associated with increased risks. Reproductive history could be considered as an indicator for risk stratification and management of cardiometabolic disease in women.
Authors
- Shaoru Li
- Wenfang Yang (ORCID: https://orcid.org/0000-0001-7799-5008)
- Yingze Zhu (ORCID: https://orcid.org/0000-0001-5571-704X)
- Zhonghai Zhu (ORCID: https://orcid.org/0000-0003-3926-2502)
- Jialu Li (ORCID: https://orcid.org/0009-0003-0030-1014)
- Lingxia Zeng (ORCID: https://orcid.org/0000-0002-4649-9818)
- Liang Wang (ORCID: https://orcid.org/0000-0003-4086-3989)
- Wenjing Qin (ORCID: https://orcid.org/0000-0001-6614-171X)
- Yuan Shen (ORCID: https://orcid.org/0000-0002-7811-1478)
- Yue Cheng (ORCID: https://orcid.org/0000-0003-2321-9753)
- Qi Qi (ORCID: https://orcid.org/0000-0003-0028-3381)
Institutions
- Xian Center for Disease Control and Prevention (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- BMC Women s Health
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12905-025-04030-5
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Key Research and Development Program of China
- Key Research and Development Projects of Shaanxi Province