Investigating the Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing Enterobacterales (ESBL-E) Among Patients Admitted to the Intensive Care Unit
At a United States hospital, sequencing of ICU rectal surveillance cultures indicated 5% ESBL-E colonization. Of confirmed ESBL isolates, 91% were <i>Escherichia coli</i> or <i>Klebsiella pneumoniae</i>; 6% carried non-<i>bla</i> <sub>CTX-M</sub> genes. Only 53% of third-generation cephalosporin-resistant Enterobacterales harbored ESBL genes, underscoring the limitations of phenotypic approaches as ESBL surrogates, particularly for non-<i>E. coli/K. pneumoniae</i> species.
Authors
- Eili Klein (ORCID: https://orcid.org/0000-0002-1304-5289)
- Sara E. Cosgrove (ORCID: https://orcid.org/0000-0001-9458-4331)
- Pranita D. Tamma (ORCID: https://orcid.org/0000-0002-4143-6324)
- Sima L. Sharara (ORCID: https://orcid.org/0000-0002-9404-0454)
- Yehudit Bergman (ORCID: https://orcid.org/0000-0002-4262-7173)
- Suiyini Fiawoo
- Patricia J. Simner (ORCID: https://orcid.org/0000-0001-6134-151X)
- Emily Jacobs
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1093/ofid/ofaf590
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- Shionogi
- National Institutes of Health
- Centers for Disease Control and Prevention