Impact of biliary drainage for unresectable pancreatic cancer treated with nanoliposomal irinotecan with fluorouracil and folinic acid: retrospective results from the NAPOLEON-2 study
BD had minimal impact on the efficacy of NFF in daily practice. Patients with total bilirubin ≥ 1.0 mg/dL had shorter OS than those with total bilirubin < 1.0 mg/dL.
Authors
- Shigeyuki Takeshita
- Kengo Tsuneyoshi
- Hiroki Taguchi
- Akiko Todaka (ORCID: https://orcid.org/0000-0002-7308-5960)
- Mototsugu Shimokawa (ORCID: https://orcid.org/0000-0001-8140-4565)
- Taro Shibuki (ORCID: https://orcid.org/0000-0001-7302-7691)
- Junichi Nakazawa
- Keisuke Miwa (ORCID: https://orcid.org/0000-0002-2456-0358)
- Takashi Inagaki (ORCID: https://orcid.org/0000-0002-6025-2571)
- Toshihiko Mizuta
- Takahiro Sakae
- Hozumi Shimokawa
- Kazuo Nishikawa (ORCID: https://orcid.org/0000-0003-1397-953X)
- Yoshihito Kubotsu
- Yujiro Ueda (ORCID: https://orcid.org/0000-0001-8340-0023)
- Takuya Honda (ORCID: https://orcid.org/0000-0002-7141-0088)
- Shuji Arita
- Tsuyoshi Shirakawa (ORCID: https://orcid.org/0000-0002-9317-8216)
- Toshihiro Fujita
- Kenji Mitsugi
- Ayumu Hosokawa (ORCID: https://orcid.org/0009-0003-6913-6950)
- Yasunori Kawaguchi
- Taiga Otsuka (ORCID: https://orcid.org/0000-0002-8552-8095)
- Azusa Komori (ORCID: https://orcid.org/0000-0003-0591-1025)
- Hisanobu Oda
- Tatsunori Sakai
- Satoshi Otsu
- Futa Koga
- Shiho Arima
- Machiko Kawahira
Institutions
- Kagoshima University (JP)
- University of Miyazaki (JP)
- Yamaguchi University (JP)
- Oita University (JP)
- Japanese Red Cross Society, Japan (JP)
- Fukuoka University (JP)
- Japan Hospital Association (JP)
- Sasebo City General Hospital (JP)
- Takamatsu Red Cross Hospital (JP)
- Kurume University Hospital (JP)
- Saiseikai Kumamoto Hospital (JP)
- Hamanomachi Hospital (JP)
- Saga-Ken Medical Centre Koseikan (JP)
- Japanese Red Cross Kumamoto Hospital (JP)
- Miyazaki Prefectural Hospital (JP)
- Kyushu Hospital (JP)
- Kagoshima City Hospital (JP)
- Ono Clinic (JP)
- Izumi City General Hospital (JP)
- Japan Community Healthcare Organization (JP)
- University of Miyazaki Hospital (JP)
- Shikoku Cancer Center (JP)
- National Cancer Center Hospital East (JP)
- Sendai Shakai Hoken Hospital (JP)
- Kumamoto Medical Center (JP)
- Nagasaki University (JP)
- ShinEtsu Chemical (Japan) (JP)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12885-025-14992-2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00