Profile of biological aging in first primary cancers: a pan-cancer analysis of two large-scale cohorts from the UK and Hong Kong
This pan-cancer study reveals intricate interrelationships between biological aging and cancer, particularly in lung, prostate, and female breast cancer, with population-specific patterns and synergistic genetic interactions. Findings underscore the potential for aging-targeted strategies in cancer prevention and treatment.
Authors
- Ada Tsui‐Lin Ng (ORCID: https://orcid.org/0009-0003-8788-6616)
- A. Lam (ORCID: https://orcid.org/0000-0001-5731-7146)
- Rong Na (ORCID: https://orcid.org/0000-0001-7470-5108)
- Xiaohao Ruan (ORCID: https://orcid.org/0000-0001-8373-5237)
- Jingyi Huang (ORCID: https://orcid.org/0000-0002-1209-9699)
- Yongle Zhan (ORCID: https://orcid.org/0000-0002-7378-1915)
- Tsun Tsun Stacia Chun (ORCID: https://orcid.org/0009-0009-6715-7815)
- Ruofan Shi (ORCID: https://orcid.org/0009-0005-1001-390X)
- Chi Yao (ORCID: https://orcid.org/0000-0002-0734-6560)
- Weiguo Hu (ORCID: https://orcid.org/0000-0002-7397-6800)
- Ruochen Ma (ORCID: https://orcid.org/0000-0002-9658-1326)
- Jia‐Cheng Liu (ORCID: https://orcid.org/0000-0002-7779-3016)
- Sk Subidh Ali (ORCID: https://orcid.org/0009-0008-6990-3546)
- Da Huang
Institutions
- Chinese University of Hong Kong (HK)
- Shanghai Jiao Tong University (CN)
- Queen Mary Hospital (CN)
- Ruijin Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12916-025-04409-z
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Impact Fund
- Hospital Authority
- Health and Medical Research Fund
- Li Ka Shing Faculty of Medicine, University of Hong Kong