Adiposity, metabolites and endometrial cancer risk: inference from combinations of Mendelian randomization and observational analyses
Evidence here suggests that higher BMI causes a higher risk of overall and all histological subtypes of EC and variation in numerous circulating metabolites. Several of these metabolites showed relationships consistent with an intermediate role between BMI and non-endometrioid EC, however, further analyses highlighted other potential shared mechanisms that could influence the risk of EC.
Authors
- Vanessa Y. Tan (ORCID: https://orcid.org/0000-0001-7938-127X)
- Matthew A. Lee (ORCID: https://orcid.org/0000-0001-6262-3447)
- Nicholas J. Timpson (ORCID: https://orcid.org/0000-0002-7141-9189)
- Laure Dossus (ORCID: https://orcid.org/0000-0003-2716-5748)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Laura J. Corbin (ORCID: https://orcid.org/0000-0002-4032-9500)
- Sabrina E. Wang (ORCID: https://orcid.org/0000-0002-6102-6234)
- Dimitri J. Pournaras (ORCID: https://orcid.org/0000-0001-8798-920X)
- Kaitlin H. Wade (ORCID: https://orcid.org/0000-0003-3362-6280)
Institutions
- North Bristol NHS Trust (GB)
- Southmead Hospital (GB)
- At Bristol (GB)
- University of Bristol (GB)
- Centre international de recherche sur le cancer (FR)
- Imperial College London (GB)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12885-025-14756-y
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Wellcome Trust
- Cancer Research UK
- National Institute for Health and Care Research
- Royal College of Surgeons of England
- University of Bristol
- Novo Nordisk
- Medical Research Council