Is Negative Fecal Immunochemical Test Reassuring? The Cumulative Risk of Colorectal Cancer after Multiple Negative Tests
Two-thirds of the 10-year CRC risk remained in individuals following one negative FIT. The risk after a negative FIT result reemerged 2 years after testing, highlighting the importance of continuing biennial FIT screening. Consistently negative FITs were associated with reduced CRC risk and a lower all-cause mortality. This study is limited by the lack of confirmatory colonoscopy in FIT-negative individuals, which may lead to an underestimation of CRC incidence.
Authors
- Min‐Kuang Tsai (ORCID: https://orcid.org/0000-0002-2528-3911)
- Christopher Wen (ORCID: https://orcid.org/0000-0001-5908-3865)
- Ta‐Wei Chu (ORCID: https://orcid.org/0000-0003-2124-6424)
- Chi Pang Wen (ORCID: https://orcid.org/0000-0001-7896-2558)
- Chien Hua Chen
Institutions
- National Chung Hsing University (TW)
- National Health Research Institutes (TW)
- China Medical University (TW)
- University of California, Irvine Medical Center (US)
- Chang Bing Show Chwan Memorial Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
Publication Details
- Journal
- Gut and Liver
- Published
- 2025-10-21
- DOI
- https://doi.org/10.5009/gnl250063
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00