Scrub typhus triggering seizure in a patient with a preexisting seizure disorder: A case report

Abstract Scrub typhus is a bacterial infection caused by Orientia tsutsugamushi and transmitted by chigger bites. It presents as an acute febrile illness and can lead to serious complications, including liver and kidney dysfunction. Although neurological involvement is rare, cases have been reported. We describe the case of a 59-year-old male from a scrub typhus endemic region with a history of seizure disorder who had experienced a fever for the last two days, multiple headaches, and seizures. Laboratory tests confirmed scrub typhus, low platelet levels, and elevated liver enzymes. The patient responded well to doxycycline and supportive care. This case highlights the need to identify scrub typhus in febrile patients with neurological symptoms to enable early diagnosis and treatment and prevent severe complications. The occurrence of scrub typhus with seizures is rare, making this case clinically significant in broadening differential diagnoses in endemic regions.