Gut inflammation is associated with structural spinal damage in axial spondyloarthritis – results from the observational SPARTAKUS cohort
In the current study, the presence of gut inflammation, assessed by F-calprotectin, was cross-sectionally associated with more structural damage in the spine in patients with axSpA, even after adjustments for known risk factors for spinal damage. Prospective studies are, however, needed to investigate whether gut inflammation may be a predictor of spinal radiographic progression in axSpA.
Authors
- Kristofer Andréasson (ORCID: https://orcid.org/0000-0001-7021-2541)
- J. Sagard (ORCID: https://orcid.org/0000-0001-7227-0665)
- Johan K. Wallman (ORCID: https://orcid.org/0000-0002-4915-2924)
- Elisabeth Mogård (ORCID: https://orcid.org/0000-0002-5706-203X)
- Mats Geijer (ORCID: https://orcid.org/0000-0003-0529-7723)
- Elisabet Lindqvist (ORCID: https://orcid.org/0000-0002-9937-6352)
- Tor Olofsson (ORCID: https://orcid.org/0000-0002-9919-4487)
- Jan Marsal (ORCID: https://orcid.org/0000-0003-4808-0014)
- Fatih Inci (ORCID: https://orcid.org/0000-0001-8629-588X)
Institutions
- Lund University (SE)
- Sahlgrenska University Hospital (SE)
- Region Västra Götaland (SE)
- Skåne University Hospital (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13075-025-03663-z
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00