Inflammatory Bowel Disease Following Allogeneic Hematopoietic Cell Transplant for Sickle Cell Disease

Although graft-versus-host disease (GvHD) is an important cause of gastrointestinal (GI) complications after allogeneic hematopoietic stem cell transplantation (HCT), the non-specific symptoms make diagnosis challenging. We described three patients with sickle cell disease who developed inflammatory bowel disease (IBD) like manifestations 4-18 months post-HCT. All patients received peripheral blood stem cell grafts and sirolimus for GvHD prophylaxis. All had chronic diarrhea, and biopsies showed extensive colonic ulceration, non-necrotizing granulomas, with minimal histologic evidence of GvHD. Symptoms resolved promptly with IBD-directed therapy. Our report highlights the importance of considering alternative rare etiologies for GI complications such as IBD after HCT.

Authors

Institutions

Publication Details

Journal
Pediatric Blood & Cancer
Published
2025-10-20
DOI
https://doi.org/10.1002/pbc.32121
Primary Topic
Hematopoietic Stem Cell Transplantation
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Inflammatory Bowel Disease Following Allogeneic Hematopoietic Cell Transplant for Sickle Cell Disease

Jeffrey E. Deyo, J Alberty, Ross Maltz, Kiran Joglekar et al.
Pediatric Blood & Cancer
Hematopoietic Stem Cell Transplantation
article

Inflammatory Bowel Disease Following Allogeneic Hematopoietic Cell Transplant for Sickle Cell Disease

Jeffrey E. Deyo, J Alberty, Ross Maltz, Kiran Joglekar, Edwin C. Rowland, Hemalatha G. Rangarajan, Akshay Sharma, Samantha Paglinco, Courtney D. Fitzhugh
article en

Abstract

Although graft-versus-host disease (GvHD) is an important cause of gastrointestinal (GI) complications after allogeneic hematopoietic stem cell transplantation (HCT), the non-specific symptoms make diagnosis challenging. We described three patients with sickle cell disease who developed inflammatory bowel disease (IBD) like manifestations 4-18 months post-HCT. All patients received peripheral blood stem cell grafts and sirolimus for GvHD prophylaxis. All had chronic diarrhea, and biopsies showed extensive colonic ulceration, non-necrotizing granulomas, with minimal histologic evidence of GvHD. Symptoms resolved promptly with IBD-directed therapy. Our report highlights the importance of considering alternative rare etiologies for GI complications such as IBD after HCT.

Pediatric Blood & CancerVol. 73(1)
Arkansas Children's Hospital (US), St. Jude Children's Research Hospital (US), Nationwide Children's Hospital (US), University of Tennessee Health Science Center (US), Our Lady of the Lake Children's Hospital (US), National Heart, Lung, and Blood Institute (US), Arkansas Children’s Foundation (US), St. Christopher's Hospital for Children (US)
Openalex Percentile: Top 62%
Hematopoietic Stem Cell Transplantation
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Inflammatory Bowel Disease Following Allogeneic Hematopoietic Cell Transplant for Sickle Cell Disease — Jeffrey E. Deyo, J Alberty, et al. · Pediatric Blood & Cancer (2025) | TGRS Research Map | TGRS