NKG2D CAR-NK adoptive cellular immunotherapy combined with or without PD-1 blockade in the treatment of patients with metastatic colorectal cancer: an exploratory study
NKG2D CAR-NK cell therapy, alone or combined with PD-1 blockade, demonstrated a favorable safety profile and potential clinical benefit in advanced CRC, warranting further investigation in larger cohorts.
Authors
- Danyang Wang (ORCID: https://orcid.org/0000-0003-4540-6656)
- Weijia Fang (ORCID: https://orcid.org/0000-0001-9849-347X)
- Yang Gao (ORCID: https://orcid.org/0000-0003-1785-5542)
- Dongxue Hu
- Xudong Zhu (ORCID: https://orcid.org/0000-0002-6657-6112)
- Xiaomeng Dai (ORCID: https://orcid.org/0000-0003-0673-1886)
- Shu Wang (ORCID: https://orcid.org/0000-0003-4107-2812)
- Бин Ли (ORCID: https://orcid.org/0000-0002-8038-0140)
- Lulu Liu (ORCID: https://orcid.org/0000-0001-9257-9512)
- Hangyu Zhang (ORCID: https://orcid.org/0000-0002-5392-8019)
- Peng Zhao (ORCID: https://orcid.org/0000-0003-2034-6810)
- Guojie Shen (ORCID: https://orcid.org/0000-0002-6324-2838)
- Yi Zheng (ORCID: https://orcid.org/0000-0002-7066-2937)
- Zhou Tong
- Xuanwen Bao
- Zhimin Du
Institutions
- Zhejiang Chinese Medical University (CN)
- Ministry of Education (TW)
- China National Silk Museum (CN)
- Hangzhou Cancer Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1007/s00262-025-04196-9
- Citations
- 7
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 7.32