Pharmacokinetics of Trelagliptin in Rats after Exposure to Acute and Chronic High Altitude Hypoxia
The study demonstrated that high-altitude hypoxia significantly altered trelagliptin's pharmacokinetics, slowing clearance, prolonging elimination half-life and residence time, and increasing bioavailability. These changes suggested that the optimal therapeutic dosage of trelagliptin should be reassessed under hypoxic exposure.
Authors
- Ya-Feng Wang (ORCID: https://orcid.org/0000-0002-4374-7054)
- Delong Duo (ORCID: https://orcid.org/0000-0001-5597-6690)
- Ni Zhao
- Guiqin Xu (ORCID: https://orcid.org/0000-0001-7438-3751)
- Ye Chang
- Zhi-Lan Huan
- Xue Wu
Institutions
- Qinghai Provincial Peoples Hospital (CN)
Publication Details
- Journal
- Current Drug Metabolism
- Published
- 2025-10-20
- DOI
- https://doi.org/10.2174/0113892002408318251002114813
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00