Study on resistance mechanisms and molecular epidemiology of carbapenem-resistant Pseudomonas aeruginosa to ceftazidime/avibactam in a certain region of China
Our findings indicate a high prevalence of CZA resistance among CRPA isolates in Ningbo, driven by multiple mechanisms including <i>bla<sub>NDM</sub></i> carriage, enhanced biofilm formation, and overexpression of efflux pumps. The dissemination of the high-risk clone ST1076 underscores the need for strengthened infection control measures to curb its spread. These findings provide important insights for optimizing infection control and treatment strategies against CRPA infections in this region.
Authors
- Xiaohui Qiao (ORCID: https://orcid.org/0000-0002-5687-3703)
- Yao Xu (ORCID: https://orcid.org/0000-0002-2122-392X)
- Xinyu Deng (ORCID: https://orcid.org/0000-0002-7948-6896)
- Wei Liang (ORCID: https://orcid.org/0000-0002-1610-0554)
- Linjin Zheng (ORCID: https://orcid.org/0000-0001-5177-4602)
- Ruobing Wang (ORCID: https://orcid.org/0000-0002-9921-7271)
- He Zhang (ORCID: https://orcid.org/0009-0004-3886-4952)
- Ting Cao
Institutions
- Ningbo University (CN)
- Bengbu Medical College (CN)
- Wenzhou Medical University (CN)
- Consultative and Diagnostic Center (RU)
- Ningbo University Affiliated Hospital (CN)
- Ningbo First Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3389/fcimb.2025.1643755
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00