Food-specific IgG antibodies and body mass index: multivariate analysis of clinical correlations in underweight populations

Food-specific IgG profiles, particularly wheat and soybean antibodies, are independently associated with nutritional status in underweight populations. These findings suggest immune-mediated pathways may contribute to malabsorption and metabolic dysregulation, supporting IgG testing for personalized dietary interventions. Study limitations include small subgroup sizes, underscoring the need for mechanistic research integrating gut microbiota analysis.