MFSD12 promotes proliferation, metastasis and invasion of hepatocellular carcinoma cells and its potential correlation with HAVCR2/LGALS9 immune checkpoint axis
Our findings demonstrated that MFSD12 upregulation in LIHC strongly correlates with poor prognosis. This association was potentially attributed to MFSD12's dual roles: promoting tumor cell proliferation, migration, and metastasis while critically modulating the tumor immune microenvironment, particularly through interaction with the HAVCR2/LGALS9 immune checkpoint axis.
Authors
- Song Wen (ORCID: https://orcid.org/0000-0001-6173-0507)
- Kai Sun (ORCID: https://orcid.org/0000-0001-9619-9007)
- Kongjia Wang (ORCID: https://orcid.org/0009-0002-0995-409X)
- Shuangping Guo (ORCID: https://orcid.org/0000-0001-6389-9568)
- Qinghua Pan (ORCID: https://orcid.org/0000-0002-0767-4089)
Institutions
- Ganzhou People's Hospital (CN)
- Gannan Medical University (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1681887
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00