Aerobic exercise and gut flora: a key link to improved cognitive impairment in mice with Parkinson’s disease
Aerobic exercise improves gut flora imbalance in PD mice. It also attenuates PD-related pathological impairments and cognitive deficits. However, its efficacy on non-motor symptoms can be nullified by antibiotics. The gut flora-mediated aerobic exercise exerts neuroprotective effects on PD by regulating FNDC5 secretion via PGC1-<i>α</i>/CREB.
Authors
- Senxiang Yan (ORCID: https://orcid.org/0000-0001-6902-0892)
- Jie Xiang (ORCID: https://orcid.org/0000-0001-8937-3564)
- Wenjun Shan (ORCID: https://orcid.org/0000-0001-5983-8455)
- Jing Wang (ORCID: https://orcid.org/0000-0001-7199-4784)
- Hui Yang (ORCID: https://orcid.org/0000-0003-2489-7572)
- Yuan Guo (ORCID: https://orcid.org/0000-0002-0027-0268)
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3389/fnagi.2025.1630003
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province