Dual adaptive strategies in Candida glabrata under tunicamycin stress: petite mutations and chromosome C aneuploidy drive transient drug resistance
<i>C. glabrata</i> survives TUN stress through unstable genetic adaptations-petite formation and aneuploidy-that are rapidly selected against in drug-free environments. These findings highlight the evolutionary constraints of antifungal resistance mechanisms and suggest that intermittent therapy may help counteract resistance development.
Authors
- Shuai Bai (ORCID: https://orcid.org/0000-0003-2170-3453)
- Yi Xu (ORCID: https://orcid.org/0000-0001-8971-9334)
- Yubo Dong (ORCID: https://orcid.org/0009-0003-3272-1363)
- Chen Wang (ORCID: https://orcid.org/0000-0002-2727-7240)
- Jing Wang (ORCID: https://orcid.org/0000-0001-9496-6276)
- Chunhua Ma (ORCID: https://orcid.org/0009-0003-3920-0720)
Institutions
- The Fourth People's Hospital of Zibo City (CN)
- 82th Hospital of Pla (CN)
- Central Hospital of Zibo (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3389/fmicb.2025.1675175
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province