Lithium chloride modulates macrophage polarization and enhances bone defect healing in the induced membrane technique by activation of Wnt/β-catenin signaling
LiCl significantly improved bone regeneration and mineralization during bone defect repair by promoting M2 macrophage polarization, activating the Wnt/β-catenin pathway, and enhancing BMSCs differentiation.
Authors
- Changpeng Xu
- Yong Qi (ORCID: https://orcid.org/0000-0002-2653-1307)
- Ran Zhang
- Shuanji Ou
- Yang Yang (ORCID: https://orcid.org/0000-0002-6899-924X)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-2001-1052)
Institutions
- Jinan University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangdong Provincial People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3389/fphar.2025.1621639
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Municipal Science and Technology Project