The selective ERβ agonist AC 186 reduces polyinosinic:polycytidylic acid (poly I:C)-induced inflammatory responses in BEAS-2B lung epithelial cells

These results suggest that AC-186 produced anti-inflammatory activity in poly I:C-stimulated BEAS-2 cells, through mechanisms involving inhibition of NF-κB and NLRP3/caspase-1/IL-1β activation. AC186 also protected BEAS-2B cells against poly I:C-mediated apoptosis and death suggesting that this compound have potentials in reducing inflammatory events associated with ARDS caused by viral infections.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2025-10-21
DOI
https://doi.org/10.3389/fphar.2025.1706638
Citations
1
Primary Topic
NF-κB Signaling Pathways
Type
article
Field-Weighted Citation Impact
0.94

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article

The selective ERβ agonist AC 186 reduces polyinosinic:polycytidylic acid (poly I:C)-induced inflammatory responses in BEAS-2B lung epithelial cells

Olumayokun A. Olajide, Hope A. Ogiogio
1 citations
Frontiers in Pharmacology
NF-κB Signaling Pathways
0.94
article

The selective ERβ agonist AC 186 reduces polyinosinic:polycytidylic acid (poly I:C)-induced inflammatory responses in BEAS-2B lung epithelial cells

Olumayokun A. Olajide, Hope A. Ogiogio
article en
1 citations

Abstract

These results suggest that AC-186 produced anti-inflammatory activity in poly I:C-stimulated BEAS-2 cells, through mechanisms involving inhibition of NF-κB and NLRP3/caspase-1/IL-1β activation. AC186 also protected BEAS-2B cells against poly I:C-mediated apoptosis and death suggesting that this compound have potentials in reducing inflammatory events associated with ARDS caused by viral infections.

Frontiers in PharmacologyVol. 16
University of Huddersfield (GB)
Royal Society of Chemistry
Openalex Percentile: Top 19%
NF-κB Signaling Pathways
0.94
DOIOpen Access PDFOpenAlex
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The selective ERβ agonist AC 186 reduces polyinosinic:polycytidylic acid (poly I:C)-induced inflammatory responses in BEAS-2B lung epithelial cells — Olumayokun A. Olajide, Hope A. Ogiogio · Frontiers in Pharmacology (2025) | TGRS Research Map | TGRS