Discovery of protease inhibitors from bacteria as novel adjuvants for oral vaccine formulations
These results demonstrate that three protease inhibitors from bacteria: Ecotin, APRin, and STA function as novel oral mucosal adjuvants capable of modulating immune responses and enhancing antigen immunogenicity.
Authors
- Lorena M. Coria (ORCID: https://orcid.org/0000-0001-5359-8382)
- Juliana Cassataro (ORCID: https://orcid.org/0000-0002-7122-869X)
- Karina A. Pasquevich (ORCID: https://orcid.org/0000-0003-4448-0977)
- Celeste Pueblas Castro
- Laura Bruno
- Helder I. Nakaya
Institutions
- Universidade de São Paulo (BR)
- National University of General San Martín (AR)
- Hospital Israelita Albert Einstein (BR)
- Fleury S.A. (Brazil) (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1679540
- Citations
- 1
- Primary Topic
- Transgenic Plants and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.23
Funders
- GlaxoSmithKline
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Universidad Nacional de San Martín