Early postoperative liver function parameters as predictors of post-hepatectomy liver failure
Bilirubin and INR on POD 3 were the strongest independent predictors of PHLF. Elevated AST and ALT on POD 3 were also valuable prognostic indicators. Relying solely on ISGLS criteria from POD 5 onward may therefore delay diagnosis and intervention. Persistently elevated transaminases should be acknowledged as early indicators of liver dysfunction and considered in future revisions of PHLF definitions.
Authors
- Katharina Vedder
- Mahmoud Halawa (ORCID: https://orcid.org/0000-0003-0569-1544)
- Flavius Șandra-Petrescu (ORCID: https://orcid.org/0000-0003-4028-2949)
- Mohamad El-Ahmar (ORCID: https://orcid.org/0000-0001-7355-4125)
- Georgi Vassilev (ORCID: https://orcid.org/0000-0002-0297-8745)
- Meik Mönnichs
- Schaima Abdelhadi (ORCID: https://orcid.org/0009-0001-7332-9240)
- V. Orth
- Maike Hermann
- Christoph Reissfelder
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- Frontiers in Surgery
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3389/fsurg.2025.1669938
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35