Chromosomal 6q loss as a prognostic biomarker in Indian uveal melanoma: an OncoScan FFPE Assay study
Uveal melanoma is the most common intraocular malignancy in adults. Prognostic markers such as monosomy 3 and chromosome 8q gain are well validated in Western cohorts but remain unproven in Indian patients. We retrospectively analysed 30 tumours (17 metastatic, 13 nonmetastatic) using the OncoScan FFPE Assay Kit. Loss of chromosome 6q was strongly associated with metastasis (odds ratios, 23.2; 95% confidence intervals, 2.5-214; P < 0.001), compared to monosomy 3 and 8q gain. Multivariate analysis confirmed 6q loss as the dominant independent predictor. These findings support population-specific prognostic models and highlight the clinical value of integrating 6q status into risk assessment.
Authors
- Sowmya Parameswaran (ORCID: https://orcid.org/0000-0002-2508-0743)
- Vikas Khetan (ORCID: https://orcid.org/0000-0003-4396-9877)
- Suganeswari Ganesan (ORCID: https://orcid.org/0000-0001-9164-9523)
- Bhavani Shankar Maradani (ORCID: https://orcid.org/0000-0002-5763-4421)
- Subramanian Krishnakumar (ORCID: https://orcid.org/0000-0002-1958-5999)
Institutions
- Sankara Nethralaya (IN)
- CODET Vision Institute (MX)
- U.S. Stem Cell (United States) (US)
Publication Details
- Journal
- Melanoma Research
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1097/cmr.0000000000001067
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00