Human platelet-derived extracellular vesicle fractions modulate bone cell metabolism and biologize volume-stable β-TCP matrix in vitro
Our data demonstrate the potential of hPLEV-F to stimulate bone cell interaction and support bone regenerative pathways, thereby suggesting it as a biologizing agent in combination with synthetic biomaterial. This creates innovative possibilities in biointerface engineering thereby advancing patient care in clinical applications.
Authors
- Kyra de Miroschedji
- S. W. Koch (ORCID: https://orcid.org/0000-0001-5473-0170)
- Annika Döding
- Ulrike Schulze‐Späte (ORCID: https://orcid.org/0000-0002-8046-0394)
- Alexander Güllich
Institutions
- Jena University Hospital (DE)
- URSAPHARM (Germany) (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12916-025-04371-w
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Leibniz-Gemeinschaft
- Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie – Hans-Knöll-Institut