NSH76: a selective inhibitor of RRN3 and RNA polymerase I transcription with potential for cancer therapy
These findings establish NSH76 as a potent and selective Pol I inhibitor with significant therapeutic potential in cancer and possible implications for overcoming chemoresistance.
Authors
- Srivatsava Naidu (ORCID: https://orcid.org/0000-0002-1441-2749)
- Prasad V. Bharatam (ORCID: https://orcid.org/0000-0002-7064-8561)
- Sheetanshu Saproo (ORCID: https://orcid.org/0000-0002-2221-1840)
- Shashanka Shekhar Sarkar (ORCID: https://orcid.org/0000-0003-1639-2371)
- Ipsita Roy (ORCID: https://orcid.org/0000-0003-1120-444X)
- Soumojit Biswas
- Mansi Sharma (ORCID: https://orcid.org/0000-0002-4026-5498)
- Kousar Jahan (ORCID: https://orcid.org/0009-0004-9884-2480)
- Arpita Karmakar
- Sakshi Nautiyal
Institutions
- Indian Institute of Technology Ropar (IN)
- National Institute of Pharmaceutical Education and Research (IN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1186/s12967-025-06588-y
- Citations
- 1
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Science and Engineering Research Board