Efficient Synthesis of Unsymmetrical 7,7′-Biindolizines
Six new unsymmetrical 7,7′-biindolizines were synthesized through an efficient metal-free [2+2+1] cycloaddition of ethyl 3-benzoyl-7-(pyridin-4-yl)indolizine-1-carboxylate with two equivalents of dimethyl acetylenedicarboxylate in methanol. The transformation involves one C≡C triple bond cleavage and provides access to previously unexplored unsymmetrical functionalized 7,7′-biindolizines.
Authors
- Roxana Ciorteanu
- Ramona Danac (ORCID: https://orcid.org/0000-0003-4370-5353)
- Ionel I. Mangalagiu (ORCID: https://orcid.org/0000-0002-4632-5076)
- Ioana Radu (ORCID: https://orcid.org/0000-0001-5219-0182)
- Catalina Ionica Ciobanu (ORCID: https://orcid.org/0000-0002-4264-9049)
- Andreea Danila
Institutions
- Alexandru Ioan Cuza University (RO)
Publication Details
- Journal
- Molbank
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3390/m2074
- Citations
- 1
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.94