PDE5A <sup>+</sup> cancer-associated fibroblasts enhance immune suppression in gastric cancer
Our study elucidates the intricate role of PDE5A<sup>+</sup> CAFs in shaping the immunosuppressive TME in GC, providing mechanistic insights and therapeutic potential for combating this aggressive malignancy.
Authors
- Jie Mei (ORCID: https://orcid.org/0000-0001-7799-8129)
- Feng‐Lai Yuan (ORCID: https://orcid.org/0000-0001-9194-8910)
- Jun-jie Wu
- Ting Shan (ORCID: https://orcid.org/0009-0002-0006-9035)
- Jingyao Hou (ORCID: https://orcid.org/0000-0002-7539-8207)
- Qian Yin (ORCID: https://orcid.org/0000-0002-6535-9861)
- Zheng-dong Yuan
- Keliang Wang
- Lihua Yu (ORCID: https://orcid.org/0000-0003-0586-3780)
- Wei Liu (ORCID: https://orcid.org/0000-0003-0004-2713)
- Chao Deng (ORCID: https://orcid.org/0000-0002-2607-5575)
- Zheng Ding (ORCID: https://orcid.org/0009-0003-4358-0295)
- Bo Gao (ORCID: https://orcid.org/0000-0002-5633-5163)
- Jichao Wang (ORCID: https://orcid.org/0000-0002-1019-9944)
- Qinglin Zhang (ORCID: https://orcid.org/0000-0002-8097-9508)
- Zhang-Feng Zhong
- Jianqing Cheng
- Yong Zhao
- Chen-jun Xie
- Jianfeng Huang
- Wenzhe Zhang (ORCID: https://orcid.org/0000-0002-8798-2195)
- Yankui Liu (ORCID: https://orcid.org/0000-0002-7295-4757)
- Chengjia Qian
Institutions
- Jiangnan University (CN)
- University of Macau (MO)
- Wuxi Fourth People's Hospital (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1136/gutjnl-2025-335794
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14