Enzymatic Behavior of Condoliase in Porcine Nucleus Pulposus: Ex Vivo and In Vitro Assessment
We demonstrated that condoliase is retained in the nucleus pulposus and exerts its pharmacological effects by locally degrading CS without degrading collagen fibers. The results obtained in this study can be useful in predicting the mechanism of the pharmacological action of condoliase in clinical practice.
Authors
- Taiichi Shirogane
- Ippei Watanabe (ORCID: https://orcid.org/0000-0002-7862-5655)
- Ko Takeda
Institutions
- Seikagaku Corporation (Japan) (JP)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-10-19
- DOI
- https://doi.org/10.1002/jsp2.70131
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Fukui
- Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu