Injury Induces More Severe Biomechanical Changes in Middle‐Aged and Geriatric Lumbar Spines in a Mouse Ex Vivo Model
We conclude that both age and injury independently and synergistically affect ex vivo biomechanical properties of mouse lumbar spine. The more severe biomechanical change in middle-aged and geriatric mouse lumbar spines suggests similar injuries may cause greater spinal dysfunction in individuals of comparable ages. These findings provide context for future in vivo studies investigating long-term effects of acute spine injuries.
Authors
- Veeraj Shah (ORCID: https://orcid.org/0009-0005-1935-0566)
- James C. Iatridis (ORCID: https://orcid.org/0000-0002-2186-0590)
- Philip Nasser
- Chitra Lekha Dahia (ORCID: https://orcid.org/0000-0003-3683-9791)
- Justin Tiao (ORCID: https://orcid.org/0000-0002-9414-7120)
- Antonia Demopoulos
- Jennifer Weiser (ORCID: https://orcid.org/0000-0002-3578-3469)
- Andrew C. Hecht (ORCID: https://orcid.org/0000-0001-5228-4568)
- Neharika Bhadouria (ORCID: https://orcid.org/0000-0002-8947-2551)
- Deepak Vashishth (ORCID: https://orcid.org/0000-0001-5712-0167)
- Bowen Wang (ORCID: https://orcid.org/0000-0003-0049-1623)
- Yunsoo Lee (ORCID: https://orcid.org/0000-0002-6039-5142)
- Charu Jain (ORCID: https://orcid.org/0009-0001-7868-2561)
- Andrew Parker Hallmark
- Angelica Baburova
Institutions
- Hospital for Special Surgery (US)
- Rensselaer Polytechnic Institute (US)
- Cornell University (US)
- Cooper Union (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-10-19
- DOI
- https://doi.org/10.1002/jsp2.70127
- Citations
- 2
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Rensselaer Polytechnic Institute
- National Institutes of Health
- NIH Office of the Director