Comparative Efficacy of High Purity Type I Collagen-Based Skin Substitute and Dehydrated Human Amnion/Chorion Membrane in Diabetic Foot Ulcers: A Multicentre Randomized Controlled Trial

In this multicentre study based on a pooled design, HPTC (Helicoll) demonstrated statistically and clinically significant superiority versus dHACM over a four-week treatment period with one-week follow-up for DFUs in terms of percent area reduction, with enhanced cellular activity, faster healing times, and improved patient quality of life. The superior healing effect of Helicoll is attributed to its high-purity type I collagen composition, providing an optimal scaffold for cellular attachment and tissue regeneration. These results align with our prior single-centre experience with Helicoll, demonstrating faster and more complete healing of DFUs compared to dHACM, showing its potential as a more effective treatment option.