Association of placental manganese levels, maternal gut microbiota, and preeclampsia: a tripartite perspective
Our findings suggest that Mn may serve as a protective factor against PE within a certain concentration range. Interactions between Mn and specific bacterial genera (<i>Coprobacillus</i>, <i>Campylobacter</i>, and <i>Porphyromonas</i>) appear to influence PE development by altering gut microbiota metabolic activities. These findings underscore the potential significance of the gut microbiota-Mn interplay in PE pathogenesis.
Authors
- Tianze Ding (ORCID: https://orcid.org/0009-0006-7425-2093)
- Shuzhen He (ORCID: https://orcid.org/0009-0004-0075-466X)
- Yuhui Dang
- Shiwei Ai (ORCID: https://orcid.org/0000-0003-2699-6355)
- Yudong Pu
- Wenting Zhao (ORCID: https://orcid.org/0000-0001-8409-3571)
- Xiaoli Huang (ORCID: https://orcid.org/0009-0009-2005-339X)
Institutions
- Guangdong Medical College (CN)
- Songshan Lake Materials Laboratory (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fmicb.2025.1674549
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00