Membraneless organelles-based integrative analysis constructs an immune-related prognostic signature and identifies NRG1 as a novel methylation biomarker in colorectal cancer
Our integrated multi-omics analysis constructed the MPRS model to delineate CRC tumor ecology and identified NRG1 as a methylation biomarker with predicted phase-separation propensity, with potential therapeutic implications that warrant prospective validation.
Authors
- Nanting Chen (ORCID: https://orcid.org/0009-0008-8801-8518)
- Yuanyuan Wan
- Weilong Chen (ORCID: https://orcid.org/0000-0001-5843-9073)
- Rui Luo (ORCID: https://orcid.org/0000-0001-5280-0999)
- Xinyi Zhu
- N Y Wang
- Chengxi Zhang (ORCID: https://orcid.org/0000-0002-7948-0275)
- Qinan Yin
- Susan Luo (ORCID: https://orcid.org/0000-0003-4356-1169)
- Guodong Liu (ORCID: https://orcid.org/0000-0001-9539-6439)
- Xue Chen (ORCID: https://orcid.org/0000-0002-4441-9159)
- Jingsong Cheng
- Ziheng Zheng (ORCID: https://orcid.org/0009-0004-9240-3751)
Institutions
- Sun Yat-sen University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Sun Yat-sen University Cancer Center (CN)
- First People's Hospital of Chongqing (CN)
- Guhua Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1678096
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87