Risk factors for angiotensin converting enzyme inhibitor angioedema in a South African population
In this South African population, Black genetic ancestry and calcium channel blocker use were the major risk factors for AE-ACEI. The majority of AE-ACEI occurred after several years of treatment, with most cases involving the lip and/or tongue. Long-term follow-up, genetic, and further mechanistic studies are warranted in additional diverse African populations.
Authors
- Jonny Peter (ORCID: https://orcid.org/0000-0002-2658-0723)
- E. Idris Jones
- Cascia Day (ORCID: https://orcid.org/0000-0002-8090-3861)
- Lovemore Mapahla (ORCID: https://orcid.org/0000-0002-0146-3299)
- Sarah Pedretti (ORCID: https://orcid.org/0000-0003-4005-8453)
- Mimi Deetlefs
- Melissa Ribeiro
- Adelein Engelbrecht
- Carrie McDougall
Institutions
- University of Cape Town (ZA)
- Stellenbosch University (ZA)
- Somerset Hospital (ZA)
- South African Tuberculosis Vaccine Initiative (ZA)
Publication Details
- Journal
- Frontiers in Allergy
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/falgy.2025.1664354
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Health, Western Cape Government