Histologic changes in systemically loaded right ventricles at time of transplantation
The primary histologic finding for the d-TGA-AS group was fibrosis, while the HLHS-F group showed predominantly hypertrophy. The temporal presentation of the patients was different, with the HLHS-F patients presenting earlier for transplant than the d-TGA-AS. These observations suggest that different histologic changes may occur in response to longstanding systemic pressures in these two anatomic subgroups of patients with systemic RV.
Authors
- Renin Chang (ORCID: https://orcid.org/0000-0003-1016-2233)
- Sushma Reddy (ORCID: https://orcid.org/0000-0003-3530-8630)
- Glenn J. Pelletier (ORCID: https://orcid.org/0000-0002-7206-069X)
- Perry S. Choi
- Danielle M. Mullis (ORCID: https://orcid.org/0000-0003-4743-0000)
- Riya Nilkant (ORCID: https://orcid.org/0009-0002-7850-9635)
- Amit Sharir (ORCID: https://orcid.org/0009-0008-2049-3179)
- Michael Ma
Institutions
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fcvm.2025.1640561
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00