Identification of genes associated with disulfidptosis in the subacute phase of spinal cord injury and analysis of potential therapeutic targets
IQGAP1 was identified as a central regulator of disulfidptosis during the subacute phase of SCI, exhibiting strong diagnostic and therapeutic potential. Its association with immune infiltration and metabolic remodeling suggests that targeting IQGAP1 may offer novel strategies for mitigating secondary injury in SCI.
Authors
- Xiaochen Su
- Yonghui Zhao (ORCID: https://orcid.org/0000-0002-9774-9936)
- Yulong Zhang (ORCID: https://orcid.org/0000-0002-7505-6370)
- Shenglong Wang (ORCID: https://orcid.org/0000-0002-8130-553X)
- Yingang Zhang (ORCID: https://orcid.org/0000-0001-9363-6144)
- Wenting Xu (ORCID: https://orcid.org/0000-0002-5795-3983)
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1642757
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00